Pasteur Colloquium Seminar: “The feedback symbiosis between the gut microbiome and the host” by Prof. Fang YAN
Update Time：2019-11-04
On November 1st, 2019, Prof. Fang YAN from Vanderbilt University Medical Center gave a seminar on the novel concept in regulation of intestinal homeostatis. Her work has established a mechanistic model of probiotic action in which an LGG-derived secretory protein, p40, transactivates epidermal growth factor (EGF) receptor in intestinal epithelial cells (IECs), which contributes to inhibiting cytokine-induced epithelial cell apoptosis, preserving barrier function, up-regulating mucin production, and stimulating IgA production, thereby, p40 prevents and treats colitis in mice. Further, the role of p40 in maintaining intestinal homeostasis by several other lactobacillus strains has been identified. Her unit findings support beneficial effects of p40 in patients with IBD, a multigenic autoinflammatory disease that has become a public health challenge with accelerating incidence worldwide. Their studies provide a proof-of-concept model advancing mechanistic understanding of the reciprocal nature of the symbiosis between the gut microbiome and the host. Such knowledge should lay a foundation for developing strategies to enhance the probiotic efficacy in maintaining intestinal health and preventing and treating intestinal inflammatory diseases.
After her presentation, Prof. Fang Yan was awarded the Pasteur Colloquium Medal by Prof. Philippe Sansonetti and a Q&A session was organized with the institute's students and postdoctoral fellows.
